Professor Paul Timpson
The Garvan Institute of Medical Research (NSW)
$450,000
2024 - 2027
The Research
Due to surgically unresectable, advanced disease being present at the time of diagnosis, pancreatic cancer is one of the most lethal forms of human cancer, with >90% of patient deaths occurring within 1 year of diagnosis. Systemic therapies are largely ineffective for inoperable disease. Recent work however at our Institute has shown that a number of patients harbour high levels of fibrosis, make them exquisitely sensitive to anti-fibrotic therapy. This may be enhanced by combination with gemcitabine/Abraxane and can only be seen when looking in live tissue.
Consequently, the development of more effective strategies to maximise this new opportunity in pancreatic cancer is urgently required.
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