The Kay Stubbs Project Grant: Exploring and Exploiting the Epigenetic Basis of Endocrine Resistant Breast Cancer

Breast Cancer

Lead Researcher: Professor Susan Clark

Institution: Garvan Insititute of Medical Research (NSW)

Funding: $353,633

Funding Duration: 2016 – 2018

The Research

Patients with estrogen receptor positive breast cancer receive endocrine therapy, however half fail to respond and relapse. Endocrine resistant cancer currently represents the most significant challenge in breast cancer treatment. We have identified an underlying molecular mechanism that determines endocrine sensitivity that we will exploit to stratify patients as responders to endocrine therapy, and use as a novel therapeutic strategy to effectively treat patients with recurrent disease.


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