Professor Barbara D Fazekas de St Groth

Prof Barbara Fazekas de St Groth MBBS BSc(Med) PhD is the head of the Translational Immunology Laboratory at the Charles Perkins Centre, University of Sydney. Her research in preclinical and clinical settings is aimed at understanding how immune cell interactions can be used predict individual patient disease profiles and responses to therapy. By comparing circulating immune cell subsets in cancer patients who subsequently prove to be sensitive or resistant to checkpoint immunotherapy, she and her team discovered an immune signature that robustly predicts response. The signature is being developed asa clinical lab test.

The laboratory is now focusing on the mechanisms that generate the immune signature in immunotherapy resistant patients and cancers, with the aim of developing new therapies to overcome immunotherapy resistance.

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